Surface-enhanced resonance Raman scattering in optical tweezers using co-axial second harmonic generation

Opt Express. 2005 May 30;13(11):4148-53. doi: 10.1364/opex.13.004148.

Abstract

Silica particles were partially coated with silver, and a suitable chromophore, such that they could be simultaneously trapped within an optical tweezers system, and emit a surface-enhanced resonance Raman scattering (SERRS) response. A standard 1064 nm TEM00 mode laser was used to trap the bead whilst a frequency doubling crystal inserted into the beam gave several microwatts of 532 nm co-linear light to excite the SERRS emission. The con fi guration has clear applications in providing apparatus that can simultaneously manipulate a particle whilst obtaining surface sensitive sensory information.