The development of an effective influenza vaccine would require the ability to protect against infection with multiple influenza viral strains. In particular, mucosal and T-cell-mediated immunity may offer a more cross-reactive vaccine approach for the prevention of epidemic or potentially pandemic influenza. Thus, it is imperative to more fully understand the molecular events that occur in the host upon infection with a live virus and, in particular, to better evaluate the role of the distinct signaling pathways involved in developing protective immune responses. The paper under evaluation here introduces the notion that activation of caspase-1 inflammasomes in the hematopoietic cells in vivo are required for the establishment of Th1, cytotoxic T-lymphocyte and IgA responses to influenza virus infection.