Scalarane-based sesterterpenoid RCE-protease inhibitors isolated from the Indonesian marine sponge Carteriospongia foliascens

J Nat Prod. 2009 Jun;72(6):1106-9. doi: 10.1021/np900042r.

Abstract

Two new 20,24-bishomo-25-norscalaranes, compounds 1 and 2, and two new and two known 20,24-bishomoscalaranes, compounds 3-6, have been isolated from the Indonesian marine sponge Carteriospongia foliascens. The structures of 1-6 were determined by spectroscopic analysis. Compounds 1 and 3-6 inhibit RCE-protease activity.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Endopeptidases / drug effects
  • Humans
  • Indonesia
  • Marine Biology
  • Molecular Structure
  • Porifera / chemistry*
  • Protease Inhibitors / chemistry
  • Protease Inhibitors / isolation & purification*
  • Protease Inhibitors / pharmacology*
  • Sesterterpenes / chemistry
  • Sesterterpenes / isolation & purification*
  • Sesterterpenes / pharmacology*

Substances

  • Protease Inhibitors
  • Sesterterpenes
  • Endopeptidases
  • RCE1 protein, human