Abstract
Two new 20,24-bishomo-25-norscalaranes, compounds 1 and 2, and two new and two known 20,24-bishomoscalaranes, compounds 3-6, have been isolated from the Indonesian marine sponge Carteriospongia foliascens. The structures of 1-6 were determined by spectroscopic analysis. Compounds 1 and 3-6 inhibit RCE-protease activity.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Animals
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Endopeptidases / drug effects
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Humans
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Indonesia
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Marine Biology
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Molecular Structure
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Porifera / chemistry*
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Protease Inhibitors / chemistry
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Protease Inhibitors / isolation & purification*
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Protease Inhibitors / pharmacology*
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Sesterterpenes / chemistry
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Sesterterpenes / isolation & purification*
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Sesterterpenes / pharmacology*
Substances
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Protease Inhibitors
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Sesterterpenes
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Endopeptidases
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RCE1 protein, human