Evaluation of anti-inflammatory effect of synthetic 1,5-bis(4-acetoxy-3-methoxyphenyl)-1,4-pentadien-3-one, HB2

Bioorg Med Chem. 2009 Jul 1;17(13):4290-5. doi: 10.1016/j.bmc.2009.05.034. Epub 2009 May 18.

Abstract

This work describes the synthesis and anti-inflammatory properties of a pentadienone derivative, HB2. The treatment with HB2 produced anti-oedematogenic, anti-inflammatory and antinociception without change locomotors performance. Finally, HB2 reduced the nitric oxide and prostaglandin E(2) production on RAW 264.7 cells stimulated with LPS without changing the cell viability. Taken together, our results show, for the first time, that HB2 can modulate the inflammatory response when administered to mice.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Analgesics / chemical synthesis
  • Analgesics / pharmacology
  • Analgesics / therapeutic use*
  • Animals
  • Anisoles / chemical synthesis
  • Anisoles / pharmacology
  • Anisoles / therapeutic use*
  • Anti-Inflammatory Agents / chemical synthesis
  • Anti-Inflammatory Agents / pharmacology
  • Anti-Inflammatory Agents / therapeutic use*
  • Cell Line
  • Cell Survival / drug effects
  • Dinoprostone / metabolism
  • Edema / chemically induced
  • Edema / drug therapy
  • Inflammation / chemically induced
  • Inflammation / drug therapy*
  • Ketones / chemical synthesis
  • Ketones / pharmacology
  • Ketones / therapeutic use*
  • Male
  • Mice
  • NF-kappa B / metabolism
  • Nitric Oxide / metabolism
  • Pain / chemically induced
  • Pain / drug therapy*

Substances

  • 1,5-bis(4-acetoxy-3-methoxyphenyl)-1,4-pentadien-3-one
  • Analgesics
  • Anisoles
  • Anti-Inflammatory Agents
  • Ketones
  • NF-kappa B
  • Nitric Oxide
  • Dinoprostone