Abstract
The gastrointestinal activity of hydroalcoholic extract (HE) of Salvia officinalis was evaluated in a model of ethanol-induced gastric lesion. HE showed excellent activity, with ID(50) 84.0 (54.8-128.9) mg/kg. The acetic acid-induced ulcer and the total acidity of the gastric secretion were also reduced by HE, and, in vitro experiments, the H(+),K(+)-ATPase activity was inhibited. Carnosol was identified as a possible active constituent for the gastroprotective effect of HE.
MeSH terms
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Abietanes / isolation & purification
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Abietanes / pharmacology
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Abietanes / therapeutic use*
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Acetic Acid
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Animals
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Anti-Ulcer Agents / isolation & purification
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Anti-Ulcer Agents / pharmacology
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Anti-Ulcer Agents / therapeutic use*
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Ethanol
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Female
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Gastric Mucosa / drug effects*
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Phytotherapy*
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Plant Extracts / chemistry
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Plant Extracts / pharmacology
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Plant Extracts / therapeutic use*
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Plant Leaves
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Proton Pump Inhibitors
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Rats
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Rats, Wistar
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Salvia officinalis / chemistry*
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Stomach Ulcer / chemically induced
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Stomach Ulcer / drug therapy*
Substances
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Abietanes
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Anti-Ulcer Agents
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Plant Extracts
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Proton Pump Inhibitors
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Ethanol
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carnosol
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Acetic Acid