Mannose-binding lectin 2 gene polymorphism in recurrent herpes simplex virus 2 infection

Hum Immunol. 2009 Apr;70(4):218-21. doi: 10.1016/j.humimm.2009.01.022. Epub 2009 Feb 4.

Abstract

Mannose-binding lectin (MBL) is a complement component and an opsonic factor recognizing and binding to herpes simplex virus 2 (HSV-2). In this study, we assessed the effect of MBL2 genotypes on the risk of recurring HSV-2 infection. The MBL2 structural variant genotype (A/O or O/O) was more common among the patients with recurrent HSV-2 infection compared with healthy controls (47% vs 26%, respectively; odds ratio [OR] = 2.6, 95% confidence interval [CI] 1.3-4.9; p = 0.005) or controls positive for HSV-2 antibodies (15%; OR 4.9, 95% CI 1.5-16; p = 0.007). Thus, we conclude that the MBL2 structural variant genotype, possibly through impaired recognition of HSV-2, seems to predispose individuals to the development of recurring HSV-2 infection.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Antibodies, Viral / analysis
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Gene Frequency
  • Genetic Predisposition to Disease
  • Genotype
  • Herpes Genitalis / genetics*
  • Herpes Genitalis / virology
  • Herpesvirus 2, Human / immunology
  • Herpesvirus 2, Human / metabolism
  • Humans
  • Immunoglobulin G / analysis
  • Linkage Disequilibrium
  • Male
  • Mannose-Binding Lectin / genetics*
  • Mannose-Binding Lectin / metabolism
  • Odds Ratio
  • Polymorphism, Genetic*
  • Recurrence
  • Young Adult

Substances

  • Antibodies, Viral
  • Immunoglobulin G
  • Mannose-Binding Lectin