A unified conceptual framework, which integrates the structural components of human performance, such as emotional processes (i.e., feelings, mood), cognitive processes and structures (e.g., knowledge architecture, long-term working memory), motor processes (coordination, endurance), and the neurophysiologic basis of these structural components (i.e., activation of cortical areas) is introduced. Recent developments in the cognitive, neurological, expertise, and emotion sciences provide a sound evidence for this conceptualization. The unified conceptual framework enables a better understanding of human performance, and allows generating applications, which share scientific validity.