Abstract
This cross-sectional study evaluated the immune status of non-vaccinated healthy infants to determine if it is possible to replace both measles vaccine (at 9 months) and measles, mumps and rubella (MMR) vaccine (at 18 months) with a single dose of MMR at 12 months. Serum samples from 566 children in Alexandria, Egypt showed a significant decrease in the seropositive rate to the 3 viral diseases with increasing age, but a significant increase in the seropositive rate among infants who were ranked 1st or 2nd in their family, full-term or born to mothers with no history of hypertension during pregnancy. We recommend administration of the first dose of MMR vaccine between 9 and 12 months of age, and a booster dose of MMR vaccine at 4 years of age.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Age Factors
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Analysis of Variance
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Child, Preschool
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Cross-Sectional Studies
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Egypt / epidemiology
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Female
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Health Planning Guidelines
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Humans
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Immunization Schedule
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Immunization, Secondary / methods
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Infant
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Infant, Newborn
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Male
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Measles / epidemiology
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Measles / immunology
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Measles / prevention & control
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Measles Vaccine* / administration & dosage
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Measles Vaccine* / immunology
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Measles-Mumps-Rubella Vaccine* / administration & dosage
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Measles-Mumps-Rubella Vaccine* / immunology
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Mumps / epidemiology
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Mumps / immunology
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Mumps / prevention & control
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Needs Assessment / organization & administration*
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Rubella / epidemiology
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Rubella / immunology
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Rubella / prevention & control
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Seroepidemiologic Studies
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Vaccination / methods*
Substances
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Measles Vaccine
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Measles-Mumps-Rubella Vaccine