This study addressed the question whether the affect evoked by social comparisons and individual differences in social comparison orientation (SCO) may predict the development of burnout over a period of one year. The participants were 93 nurses (25 males and 68 females) who filled out a questionnaire twice, with an interval of about one year. Comparisons with others performing better than oneself (upward comparisons) were reported to occur more often, to evoke more positive affect, and to invoke less negative affect than comparisons with others performing worse than oneself (downward comparisons). Those who responded at Time 1 (T1) with more positive affect to upward comparison and with less negative affect to downward comparisons, showed a decrease in burnout at Time 2 (T2). In addition, those who responded with relatively more negative affect to upward comparisons at T1, showed an increase in burnout at T2, but only when they were high in SCO. It is concluded that in this population upward comparisons were more prevalent than, and evoked more favorable responses than, downward comparisons. The most important conclusion is that the affect evoked by social comparisons may predict future changes in burnout.