Optobionic vision--a new genetically enhanced light on retinal prosthesis

J Neural Eng. 2009 Jun;6(3):035007. doi: 10.1088/1741-2560/6/3/035007. Epub 2009 May 20.

Abstract

The recent discovery that neurons can be photostimulated via genetic incorporation of artificial opsins is creating a revolution in the field of neural stimulation. In this paper we show its potential in the field of retinal prosthesis. We show that we need typically 100 mW cm(-2) in instantaneous light intensity on the neuron in order to stimulate action potentials. We also show how this can be reduced down to safe levels in order to negate thermal and photochromic damage to the eye. We also describe a gallium nitride LED light source which is also able to generate patterns of the required intensity in order to transfer reliable images.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Biomedical Engineering / instrumentation
  • Bionics / instrumentation*
  • Blindness / rehabilitation*
  • Cells, Cultured
  • Humans
  • Lighting / instrumentation*
  • Lighting / methods
  • Photic Stimulation / instrumentation*
  • Photic Stimulation / methods
  • Prostheses and Implants*
  • Prosthesis Design / methods
  • Rats
  • Retinal Ganglion Cells / physiology*
  • Retinal Ganglion Cells / radiation effects*