Sesquiterpene lactone 12,8-eudesmanolides from the fungus Xylaria ianthinovelutina

Planta Med. 2009 Oct;75(13):1431-5. doi: 10.1055/s-0029-1185698. Epub 2009 May 18.

Abstract

The investigation of Xylaria ianthinovelutina (Mont.) led to the isolation of four new 12,8-eudesmanolides (1-4). Their structures were determined by spectroscopy and the relative stereochemistry was assigned based on NOESY and CD spectral data. Compounds 1-4 exhibited biological activity against Plasmodium falciparum K-1 strain, NCI-H187, KB, MCF-7 with IC(50) values varying in the range 0.78-19.15 microg/mL.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antimalarials / isolation & purification*
  • Antimalarials / pharmacology
  • Antimalarials / therapeutic use
  • Antineoplastic Agents / isolation & purification*
  • Antineoplastic Agents / pharmacology
  • Antineoplastic Agents / therapeutic use
  • Cell Line, Tumor
  • Humans
  • Inhibitory Concentration 50
  • Lactones / isolation & purification
  • Lactones / pharmacology
  • Lactones / therapeutic use
  • Molecular Structure
  • Neoplasms / drug therapy
  • Plasmodium falciparum / drug effects*
  • Sesquiterpenes / isolation & purification
  • Sesquiterpenes / pharmacology
  • Sesquiterpenes / therapeutic use
  • Xylariales / chemistry*

Substances

  • Antimalarials
  • Antineoplastic Agents
  • Lactones
  • Sesquiterpenes