Abstract
The investigation of Xylaria ianthinovelutina (Mont.) led to the isolation of four new 12,8-eudesmanolides (1-4). Their structures were determined by spectroscopy and the relative stereochemistry was assigned based on NOESY and CD spectral data. Compounds 1-4 exhibited biological activity against Plasmodium falciparum K-1 strain, NCI-H187, KB, MCF-7 with IC(50) values varying in the range 0.78-19.15 microg/mL.
Georg Thieme Verlag KG Stuttgart-New York.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antimalarials / isolation & purification*
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Antimalarials / pharmacology
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Antimalarials / therapeutic use
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Antineoplastic Agents / isolation & purification*
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Antineoplastic Agents / pharmacology
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Antineoplastic Agents / therapeutic use
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Cell Line, Tumor
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Humans
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Inhibitory Concentration 50
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Lactones / isolation & purification
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Lactones / pharmacology
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Lactones / therapeutic use
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Molecular Structure
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Neoplasms / drug therapy
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Plasmodium falciparum / drug effects*
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Sesquiterpenes / isolation & purification
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Sesquiterpenes / pharmacology
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Sesquiterpenes / therapeutic use
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Xylariales / chemistry*
Substances
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Antimalarials
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Antineoplastic Agents
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Lactones
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Sesquiterpenes