By using wavelet transform and remote sensing techniques, the influence of climate change on the unique mosaic landscape of sand land-wetland in middle-east Inner Mongolia in 1961 -2005 was studied. The results showed that in 1961-2005, the annual air temperature in study area had an increment of 0.32 degrees C x (10 a)(-1), the annual precipitation fluctuated with a cycle of 30 years and of 15 years, and the annual average wind speed decreased by 0.26 m x s(-1) x (10 a)(-1). In the southeast part of study area, which located in the places between Hunshandake sand land and Keerqin Deserts, there was a district, in which, the climatic characteristics did not change evidently. Until 2010, the study area would still have an increasing air temperature, lesser precipitation, and decreasing wind speed. Under the influence of warming and drying, the total area of Hunshandake sand land and the wetland around reduced year after year, and, with the vegetation degradation on sand land, wetland shrunk and lake dried up, moving sand land enlarged ceaselessly, while immovable and semi-moving sand lands reduced obviously.