Abstract
Acyclic 2'-azanucleosides with a phosphonomethoxy function in the side chain were obtained by coupling of diethyl {2-[N-(pivaloyloxymethyl)-N-(p-toluenesulfonyl)amino]ethoxymethyl}phosphonate with the pyrimidine nucleobases via the Vorbrüggen-type protocol. The compounds were evaluated in vitro for activity against a broad variety of RNA and DNA viruses.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acids, Acyclic / chemical synthesis
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Acids, Acyclic / chemistry*
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Acids, Acyclic / pharmacology
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Adenine / analogs & derivatives
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Adenine / chemistry
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Adenine / pharmacology
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Antiviral Agents* / chemical synthesis
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Antiviral Agents* / chemistry
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Antiviral Agents* / pharmacology
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Aza Compounds* / chemical synthesis
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Aza Compounds* / chemistry
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Aza Compounds* / pharmacology
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Cidofovir
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Cytosine / analogs & derivatives
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Cytosine / chemistry
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Cytosine / pharmacology
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DNA Viruses / drug effects*
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HeLa Cells
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Humans
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Molecular Structure
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Nucleosides / chemical synthesis
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Nucleosides / chemistry*
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Nucleosides / pharmacology
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Organophosphonates / chemical synthesis
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Organophosphonates / chemistry*
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Organophosphonates / pharmacology
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RNA Viruses / drug effects*
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Tenofovir
Substances
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Acids, Acyclic
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Antiviral Agents
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Aza Compounds
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Nucleosides
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Organophosphonates
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adefovir
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Cytosine
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Tenofovir
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Adenine
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Cidofovir