Abstract
The cardioprotective and endothelioprotective effects of the macrolide antibiotics roxithromycin, azythromycin, and midecamycin have been studied on laboratory animals with models of the coronaro-occlusional myocardial infarction and endothelial dysfunction. The drugs led to a dose-dependent decrease in lethality, reduced the zone of necrosis of the left ventricle after coronary occlusion, and produced a positive effect on the functioning of endothelium.
MeSH terms
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Animals
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Anti-Bacterial Agents / therapeutic use*
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Azithromycin / therapeutic use*
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Cardiotonic Agents / therapeutic use*
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Coronary Occlusion / complications
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Endothelium, Vascular / drug effects*
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Endothelium, Vascular / physiopathology
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Leucomycins / therapeutic use*
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Male
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Myocardial Infarction / drug therapy*
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Myocardial Infarction / etiology
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Myocardial Infarction / physiopathology
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Rats
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Rats, Wistar
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Roxithromycin / therapeutic use*
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Ventricular Function, Left / drug effects
Substances
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Anti-Bacterial Agents
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Cardiotonic Agents
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Leucomycins
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Roxithromycin
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Azithromycin
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midecamycin