Diffusion-weighted imaging of kainic acid lesions in the rat brain

Magn Reson Med. 1991 Jul;20(1):158-64. doi: 10.1002/mrm.1910200117.

Abstract

We present T2-weighted and diffusion-weighted images of kainic acid lesions in the rat brain. Our observations show improved image contrast between edematous lesions and unaffected tissue using diffusion-weighted imaging. Furthermore, we show that the anisotropic intensity changes associated with this sequence can be used to highlight white matter tracts and to provide information concerning their orientation in the rat brain.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amygdala / drug effects
  • Amygdala / pathology
  • Animals
  • Brain / drug effects*
  • Brain / pathology
  • Corpus Callosum / drug effects
  • Corpus Callosum / pathology
  • Corpus Striatum / drug effects
  • Corpus Striatum / pathology
  • Diffusion
  • Kainic Acid / adverse effects*
  • Magnetic Resonance Spectroscopy*
  • Male
  • Nerve Degeneration
  • Putamen / drug effects
  • Putamen / pathology
  • Rats
  • Rats, Inbred Strains

Substances

  • Kainic Acid