Abstract
Simplify, simplify, simplify! Pretubulysin (structure without the green substituents), a simplified tubulysin was prepared in the laboratory and also found in a natural myxobacterial source. This biosynthetic precursor of the tubulysins is not as active as tubulysins A and D but is still effective in picomolar concentrations against cancer cell lines.
MeSH terms
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Amino Acid Sequence
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Antineoplastic Agents / chemical synthesis*
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology
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Cell Line, Tumor
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Drug Screening Assays, Antitumor
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Humans
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Myxococcales / chemistry*
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Oligopeptides / chemical synthesis
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Oligopeptides / chemistry*
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Prodrugs / chemical synthesis
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Prodrugs / chemistry
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Protein Precursors / chemical synthesis*
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Protein Precursors / chemistry
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Protein Precursors / pharmacology
Substances
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Antineoplastic Agents
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Oligopeptides
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Prodrugs
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Protein Precursors