Diabetes mellitus is a chronic, incurable disorder, but can be successfully managed to improve patient's quality of life and extend lifetime. Late diabetic complications that affect various organs can be postponed with appropriate treatment. HbA(1C) value tells us about glucoregulation in last 3-4 month and it helps us in estimating the treatment efficiency. In last several years number of type 2 diabetics increased in the world and also in our country. Treatment approach must be aggressive to prevent late diabetic complications in type 2 diabetes. Type 2 diabetics can be treated with oral medications as monotherapy, or in various combinations as long as the following values can be maintained: HbA(1C) value under 7%, fasting blood glucose under 6.0 mmol/l and postprandial blood glucose under 8.9 mmol/l. Insulin treatment should be introduced when HbA(1C) value gets above 7%.