Oral bisphosphonate-related osteonecrosis of the jaws: favorable outcome after bisphosphonate holiday

Quintessence Int. 2009 Apr;40(4):277-8.

Abstract

Bisphosphonate holiday has been suggested as a treatment modality for oral bisphosphonate-related osteonecrosis; however, there is debate that it can undermine beneficial effects of bisphosphonate therapy. A case successfully treated after bisphosphonate holiday is presented.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Oral
  • Aged
  • Alendronate / administration & dosage*
  • Alendronate / adverse effects
  • Bone Density Conservation Agents / administration & dosage*
  • Bone Density Conservation Agents / adverse effects
  • Collagen Type I / blood
  • Drug Administration Schedule
  • Female
  • Humans
  • Mandibular Diseases / blood
  • Mandibular Diseases / chemically induced
  • Mandibular Diseases / therapy*
  • Osteonecrosis / blood
  • Osteonecrosis / chemically induced
  • Osteonecrosis / therapy*
  • Osteoporosis, Postmenopausal / drug therapy
  • Peptides / blood

Substances

  • Bone Density Conservation Agents
  • Collagen Type I
  • Peptides
  • collagen type I trimeric cross-linked peptide
  • Alendronate