Objective: To study the relationship of nonsyndromic cleft lip and/or palate (NSCL/P) and poliovirus receptor-related 1 exon3 (PVRL1exon3) polymorphisms in Han People of Jiangzhe area.
Methods: PVRL1exon3 was examined by polymerase chain reaction-single strand conformation polymorphism (PCR-SSCP) technique in the 50 patients with NSCL/P and 85 healthy parents.
Results: No W185X mutation was found in the PVRL1exon 3.
Conclusion: It indicates that there is no relationship between NSCL/P and PVRL1exon3 in Han People in Jiangzhe area.