IL-21: a new player in the control of isotype switch in Peyer's patches

J Leukoc Biol. 2009 May;85(5):739-43. doi: 10.1189/jlb.0109045.

Abstract

Peyer's patches (PP) are lymphoid follicles of the small intestine containing predominantly IgA(+) B cells. In this JLB issue, IL-21 is reported to dampen TGF-beta1-induced IgG2b but not IgA production by mouse B cells, possibly explaining why IgA(+) B cells predominate in PP.

Publication types

  • Review

MeSH terms

  • Animals
  • B-Lymphocytes / immunology
  • B-Lymphocytes / metabolism
  • Immunoglobulin A / biosynthesis
  • Immunoglobulin Class Switching*
  • Immunoglobulin G / biosynthesis
  • Immunoglobulin Isotypes / immunology
  • Immunoglobulin Isotypes / metabolism*
  • Interleukins / immunology
  • Interleukins / metabolism*
  • Mice
  • Peyer's Patches / immunology
  • Peyer's Patches / metabolism*
  • Transforming Growth Factor beta1 / immunology
  • Transforming Growth Factor beta1 / metabolism

Substances

  • Immunoglobulin A
  • Immunoglobulin G
  • Immunoglobulin Isotypes
  • Interleukins
  • Transforming Growth Factor beta1
  • interleukin-21