Abstract
Peyer's patches (PP) are lymphoid follicles of the small intestine containing predominantly IgA(+) B cells. In this JLB issue, IL-21 is reported to dampen TGF-beta1-induced IgG2b but not IgA production by mouse B cells, possibly explaining why IgA(+) B cells predominate in PP.
MeSH terms
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Animals
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B-Lymphocytes / immunology
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B-Lymphocytes / metabolism
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Immunoglobulin A / biosynthesis
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Immunoglobulin Class Switching*
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Immunoglobulin G / biosynthesis
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Immunoglobulin Isotypes / immunology
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Immunoglobulin Isotypes / metabolism*
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Interleukins / immunology
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Interleukins / metabolism*
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Mice
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Peyer's Patches / immunology
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Peyer's Patches / metabolism*
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Transforming Growth Factor beta1 / immunology
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Transforming Growth Factor beta1 / metabolism
Substances
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Immunoglobulin A
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Immunoglobulin G
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Immunoglobulin Isotypes
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Interleukins
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Transforming Growth Factor beta1
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interleukin-21