The purpose of this study was to compare the performance of mouse pointing and selecting in the tasks with different index of difficulty between 20 pupils with intellectual disabilities and 21 pupils without disabilities. A mouse proficiency assessment software was utilized to collect data. Pupils with intellectual disabilities executed tasks more correctly in bigger target even in tasks with the same index of difficulty. The group with intellectual disabilities performed worse in cursor control even when only those correctly completed tasks were used for comparison. However, a similar pattern was observed in the performance of the group without disabilities.