Abstract
The pups from 32 litters of SD rats were given 0, 1, 3 or 10mg/kg-d of cyclosporin by oral gavage from 4 to 28 days of age. 10mg/kg-d resulted in a persistent impairment of the primary antibody response at 10 weeks of age. Indications of systemic toxicity, including the death of 10/64 pups and severely depressed weight gain, were also observed at this dose level. Arteriopathy of the heart and tubular basophilia and edema in the cortico-medullary region of the kidney were observed at 3 and 10mg/kg-d. In conclusion, while pharmacological effects were seen at all dose levels, the adverse effects of cyclosporin on the development of the immune system in the rat only occurred at a dose level that also induced systemic toxicity.
MeSH terms
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Administration, Oral
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Animals
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Animals, Newborn
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Animals, Suckling
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Anti-Bacterial Agents / toxicity*
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Antibody Formation / drug effects
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Body Weight / drug effects
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Cyclosporine / toxicity*
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Female
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Heart / drug effects
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Immune System / drug effects*
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Immune System / growth & development
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Kidney / drug effects
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Kidney / pathology
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Longevity / drug effects
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Lymph Nodes / drug effects
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Lymph Nodes / pathology
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Male
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Rats
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Rats, Sprague-Dawley
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Recovery of Function
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Sexual Maturation / drug effects
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Spleen / drug effects
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Spleen / pathology
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T-Lymphocyte Subsets / drug effects
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T-Lymphocyte Subsets / immunology
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T-Lymphocyte Subsets / pathology
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Thymus Gland / drug effects
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Thymus Gland / pathology
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Tibia / drug effects
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Tibia / growth & development
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Toxicity Tests / methods*
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Withholding Treatment
Substances
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Anti-Bacterial Agents
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Cyclosporine