Abstract
Testosterone secreting tumours of the adrenal glands are usually adrenal carcinomas or adenomas. Here we report the rare case of an adrenal ganglioneuroma with ectopic Leydig cells, a so-called virilizing adrenal ganglioneuroma. Clinically it is characterized by symptoms of virilization, histologically by the occurrence of a population of eosinophilic cells. In the absence of crystalloids of Reinke this cell population can be identified as Leydig cells based on positive immunohistochemical staining of inhibin and calretinin.
MeSH terms
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Adrenal Cortex / pathology
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Adrenal Gland Diseases / pathology
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Adrenal Gland Diseases / surgery
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Adrenal Gland Neoplasms / metabolism*
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Adrenal Gland Neoplasms / pathology*
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Adrenal Gland Neoplasms / surgery
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Adrenalectomy
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Aged
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Biomarkers, Tumor / analysis
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Calbindin 2
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Choristoma / pathology
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Choristoma / surgery
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Diagnosis, Differential
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Female
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Ganglioneuroma / metabolism*
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Ganglioneuroma / pathology*
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Ganglioneuroma / surgery
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Humans
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Inhibins / analysis
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Laparoscopy
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Leydig Cells
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Male
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S100 Calcium Binding Protein G / analysis
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Testosterone / metabolism*
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Tomography, X-Ray Computed
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Virilism / pathology*
Substances
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Biomarkers, Tumor
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CALB2 protein, human
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Calbindin 2
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S100 Calcium Binding Protein G
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Testosterone
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Inhibins