Total synthesis and determination of the absolute configuration of FD-838, a naturally occurring azaspirobicyclic product

Yujiro Hayashi; Kuppusamy Sankar; Hayato Ishikawa; Yuriko Nozawa; Kazutoshi Mizoue; Hideaki Kakeya

doi:10.1016/j.bmcl.2009.03.154

Total synthesis and determination of the absolute configuration of FD-838, a naturally occurring azaspirobicyclic product

Bioorg Med Chem Lett. 2009 Jul 15;19(14):3863-5. doi: 10.1016/j.bmcl.2009.03.154. Epub 2009 Apr 5.

Authors

Yujiro Hayashi¹, Kuppusamy Sankar, Hayato Ishikawa, Yuriko Nozawa, Kazutoshi Mizoue, Hideaki Kakeya

Affiliation

¹ Department of Industrial Chemistry, Faculty of Engineering, Tokyo University of Science, Tokyo, Japan. hayashi@ci.kagu.tus.ac.jp

PMID: 19394824
DOI: 10.1016/j.bmcl.2009.03.154

Abstract

The first asymmetric total synthesis of FD-838, a naturally occurring azaspirobicyclic product, has been accomplished allowing determination of its absolute stereochemistry.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antifungal Agents / chemical synthesis*
Antifungal Agents / chemistry
Furans / chemical synthesis*
Furans / chemistry
Imidazoles / chemical synthesis*
Imidazoles / chemistry
Molecular Conformation

Substances

Antifungal Agents
FD 838
Furans
Imidazoles