A novel HLA-Cw*07 variant, HLA-Cw*0760, identified by sequence-based typing in a bone marrow donor

Tissue Antigens. 2009 Aug;74(2):172-3. doi: 10.1111/j.1399-0039.2008.01208.x. Epub 2009 Apr 21.

Abstract

We report the identification of the novel allele HLA-Cw*0760 that was found during confirmatory high-resolution sequence-based typing of a bone marrow donor. The Cw*0760 allele has two nucleotide changes from Cw*070101 at positions 341 and 343 in exon 2, resulting in two amino acid changes from Asp to Ala (codon 90: GAC-->GCC) and Gly to Arg (codon 91: GGG-->AGG).

Publication types

  • Case Reports

MeSH terms

  • Alleles
  • Base Sequence
  • Bone Marrow* / immunology
  • HLA-C Antigens / genetics*
  • Histocompatibility Testing / methods*
  • Humans
  • Molecular Sequence Data
  • Polymorphism, Single Nucleotide*
  • Sequence Analysis, DNA
  • Sequence Homology, Nucleic Acid
  • Tissue Donors*

Substances

  • HLA-C Antigens