Bisnicalaterine A, a vobasine-vobasine bisindole alkaloid from Hunteria zeylanica

Alfarius E Nugroho; Yusuke Hirasawa; Nobuo Kawahara; Yukihiro Goda; Khalijah Awang; A Hamid A Hadi; Hiroshi Morita

doi:10.1021/np900115q

Bisnicalaterine A, a vobasine-vobasine bisindole alkaloid from Hunteria zeylanica

J Nat Prod. 2009 Aug;72(8):1502-6. doi: 10.1021/np900115q.

Authors

Alfarius E Nugroho¹, Yusuke Hirasawa, Nobuo Kawahara, Yukihiro Goda, Khalijah Awang, A Hamid A Hadi, Hiroshi Morita

Affiliation

¹ Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41 Shinagawa, Tokyo 142-8501, Japan.

PMID: 19388660
DOI: 10.1021/np900115q

Abstract

A new bisindole alkaloid, bisnicalaterine A (1), consisting of two vobasine-type skeletons, and 3-epivobasinol (2) and 3-O-methylepivobasinol (3), with vobasine-type skeletons, were isolated from the leaves of Hunteria zeylanica, and their structures were elucidated on the basis of spectroscopic data and chemical correlation. Bisnicalaterine A showed moderate cytotoxicity against various human cancer cell lines.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antineoplastic Agents, Phytogenic / chemistry
Antineoplastic Agents, Phytogenic / isolation & purification*
Antineoplastic Agents, Phytogenic / pharmacology
Apocynaceae / chemistry*
Drug Screening Assays, Antitumor
Humans
Indole Alkaloids / chemistry
Indole Alkaloids / isolation & purification*
Indole Alkaloids / pharmacology
Malaysia
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Plant Leaves / chemistry
Plants, Medicinal / chemistry*

Substances

Antineoplastic Agents, Phytogenic
Indole Alkaloids
bisnicalaterine A
vobasine