Abstract
A new coumarinolignan glucoside named yinxiancaoside C, along with five known benzofuran lignans, have been isolated from the whole plant of Chloranthus japonicus Sieb. The structures of compounds 1-6 were elucidated by chemical and spectroscopic methods including 1D-NMR, 2D-NMR, ESI-MS and HR-ESI-MS. Five known benzofuran lignans were firstly discovered in the Chloranthaceae. In addition, the cytotoxic activity of the isolated compounds against human hepatoma (Hepg-2), ovarian carcinoma (OV420), and breast cancer (MCF-7) cells was investigated by MTT method.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification*
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Antineoplastic Agents, Phytogenic / pharmacology
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Benzofurans / chemistry
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Benzofurans / isolation & purification*
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Benzofurans / pharmacology
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Cell Line, Tumor
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Cell Survival / drug effects
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Humans
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Inhibitory Concentration 50
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Lignans / chemistry
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Lignans / isolation & purification*
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Lignans / pharmacology
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Magnetic Resonance Spectroscopy
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Magnoliopsida / chemistry*
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Molecular Structure
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Spectrometry, Mass, Electrospray Ionization
Substances
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Antineoplastic Agents, Phytogenic
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Benzofurans
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Lignans