Antitumor compounds from actinomycetes: from gene clusters to new derivatives by combinatorial biosynthesis

Nat Prod Rep. 2009 May;26(5):628-60. doi: 10.1039/b822528a. Epub 2009 Feb 27.

Abstract

Covering: up to October 2008. Antitumor compounds produced by actinomycetes and novel derivatives generated by combinatorial biosynthesis are reviewed (with 318 references cited.) The different structural groups for which the relevant gene clusters have been isolated and characterized are reviewed, with a description of the strategies used for the generation of the novel derivatives and the activities of these compounds against tumor cell lines.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Actinobacteria / chemistry*
  • Actinobacteria / genetics
  • Antibiotics, Antineoplastic* / chemical synthesis
  • Antibiotics, Antineoplastic* / isolation & purification
  • Antibiotics, Antineoplastic* / pharmacology
  • Combinatorial Chemistry Techniques
  • Drug Design
  • Drug Screening Assays, Antitumor
  • Molecular Structure

Substances

  • Antibiotics, Antineoplastic