Neuroleptic-induced tardive cervical dystonia: clinical series of 20 patients

Can J Neurol Sci. 2009 Mar;36(2):222-6. doi: 10.1017/s0317167100006582.

Abstract

Background: Cervical dystonia (CD) may be classified according to the underlying cause into primary or secondary CD. Previous exposure to neuroleptics is one of the main causes of adult-onset secondary dystonia. There are few reports that characterize the clinical features of primary CD and secondary neuroleptic-induced CD. Herein our aim was to investigate a series of patients with neuroleptic induced tardive CD and to describe their clinical and demographic features.

Patients and methods: We retrospectively evaluated 20 patients with neuroleptic-induced tardive CD and compared clinical, demographic and therapeutic characteristics to another 77 patients with primary CD. All patients underwent Botulinum toxin type-A therapy.

Results: We did not identify any relevant clinical and demographic characteristics in our group of patients that could be used to distinguish tardive and primary CD.

Conclusion: Patients with tardive CD presented demographic characteristics and disease course similar to those with primary CD.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Antipsychotic Agents / adverse effects*
  • Botulinum Toxins, Type A / therapeutic use
  • Demography
  • Dyskinesia, Drug-Induced / classification
  • Dyskinesia, Drug-Induced / drug therapy
  • Dyskinesia, Drug-Induced / etiology*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Neck
  • Neuromuscular Agents / therapeutic use
  • Retrospective Studies
  • Torticollis / classification
  • Torticollis / drug therapy
  • Torticollis / etiology*

Substances

  • Antipsychotic Agents
  • Neuromuscular Agents
  • Botulinum Toxins, Type A