Photinides A-F, cytotoxic benzofuranone-derived gamma-lactones from the plant endophytic fungus Pestalotiopsis photiniae

Gang Ding; Zhihui Zheng; Shuchun Liu; Hua Zhang; Liangdong Guo; Yongsheng Che

doi:10.1021/np900084d

Photinides A-F, cytotoxic benzofuranone-derived gamma-lactones from the plant endophytic fungus Pestalotiopsis photiniae

J Nat Prod. 2009 May 22;72(5):942-5. doi: 10.1021/np900084d.

Authors

Gang Ding¹, Zhihui Zheng, Shuchun Liu, Hua Zhang, Liangdong Guo, Yongsheng Che

Affiliation

¹ Key Laboratory of Systematic Mycology & Lichenology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100080, People's Republic of China.

PMID: 19371070
DOI: 10.1021/np900084d

Abstract

Photinides A-F (1-6), six new unique benzofuranone-derived gamma-lactones, have been isolated from the crude extract of the plant endophytic fungus Pestalotiopsis photiniae. The structures of these compounds were elucidated primarily by NMR spectroscopy, and their absolute configurations were assigned by application of the CD excitation chirality method. Compounds 1-6 displayed modest cytotoxic effects against the human tumor cell line MDA-MB-231.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents / chemistry
Antineoplastic Agents / isolation & purification*
Antineoplastic Agents / pharmacology
Benzofurans / chemistry
Benzofurans / isolation & purification*
Benzofurans / pharmacology
China
Drug Screening Assays, Antitumor
Humans
Lactones / chemistry
Lactones / isolation & purification*
Lactones / pharmacology
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Plants / microbiology
Stereoisomerism
Xylariales / chemistry*

Substances

Antineoplastic Agents
Benzofurans
Lactones