An antibacterial and antifungal phenylpropanoid from Carum montanum (Coss. et Dur.) Benth. et Hook

Phytother Res. 2009 Dec;23(12):1726-30. doi: 10.1002/ptr.2820.

Abstract

The volatile constituents of the aerial parts of Carum montanum (Coss. et Dur.) Benth. et Hook. were analysed by GC-FID and GC-MS, and the main component was isolated and identified as nothoapiole. The antibacterial and antifungal activities of this compound and of the total oil were investigated against Gram-negative (P. aeruginosa, E. coli), Gram-positive (E. faecalis, S. aureus, S. epidermitis, S. saprophyticus, S. simulans, S. lugdunensis) bacteria and on one strain of fungus (C. tropicalis).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / isolation & purification
  • Anti-Bacterial Agents / pharmacology*
  • Antifungal Agents / isolation & purification
  • Antifungal Agents / pharmacology*
  • Candida tropicalis / drug effects
  • Carum / chemistry*
  • Gram-Negative Bacteria / drug effects
  • Gram-Positive Bacteria / drug effects
  • Microbial Sensitivity Tests
  • Molecular Structure
  • Oils, Volatile / pharmacology
  • Phenylpropionates / isolation & purification
  • Phenylpropionates / pharmacology*
  • Plant Oils / pharmacology

Substances

  • Anti-Bacterial Agents
  • Antifungal Agents
  • Oils, Volatile
  • Phenylpropionates
  • Plant Oils
  • nothoapiole