Circadian biology: an unexpected invitee to new time zones

Satoru Masubuchi; Paolo Sassone-Corsi

doi:10.1016/j.cub.2009.02.016

Circadian biology: an unexpected invitee to new time zones

Curr Biol. 2009 Apr 14;19(7):R298-300. doi: 10.1016/j.cub.2009.02.016.

Authors

Satoru Masubuchi¹, Paolo Sassone-Corsi

Affiliation

¹ Department of Pharmacology, School of Medicine, University of California, Irvine, CA 92697, USA.

PMID: 19368876
DOI: 10.1016/j.cub.2009.02.016

Abstract

Adaptation to changing light conditions is a hallmark of the circadian clock. A new study points to the critical role played by a transcriptional repressor previously implicated in cell differentiation, highlighting unappreciated links between the clock and the control of development and tumorigenesis.

Publication types

Comment

MeSH terms

ARNTL Transcription Factors
Animals
Basic Helix-Loop-Helix Transcription Factors / genetics
Basic Helix-Loop-Helix Transcription Factors / metabolism
Behavior, Animal / physiology
Biological Clocks / physiology*
CLOCK Proteins
Circadian Rhythm / physiology*
Gene Expression Regulation
Humans
Inhibitor of Differentiation Protein 2 / genetics
Inhibitor of Differentiation Protein 2 / metabolism
Intracellular Signaling Peptides and Proteins / genetics
Intracellular Signaling Peptides and Proteins / metabolism
Mice
Period Circadian Proteins
Time Factors
Trans-Activators / genetics
Trans-Activators / metabolism

Substances

ARNTL Transcription Factors
BMAL1 protein, human
Bmal1 protein, mouse
Basic Helix-Loop-Helix Transcription Factors
Idb2 protein, mouse
Inhibitor of Differentiation Protein 2
Intracellular Signaling Peptides and Proteins
PER1 protein, human
Per1 protein, mouse
Period Circadian Proteins
Trans-Activators
CLOCK Proteins
CLOCK protein, human
Clock protein, mouse