Abstract
We determined the prevalence of fluoroquinolone resistance among the isolates of Mycobacterium tuberculosis from 605 pulmonary tuberculosis patients in Shanghai, China. Mutations in gyrA were found in 81.5% of phenotypically fluoroquinolone-resistant isolates and were used as a molecular marker of fluoroquinolone resistance. gyrA mutations were detected in 1.9% of strains pan-susceptible to first-line drugs and 25.1% of multidrug-resistant strains. Fluoroquinolone resistance was independently associated with resistance to at least one first-line drug and prior tuberculosis treatment.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Antitubercular Agents / pharmacology*
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Case-Control Studies
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China
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DNA Gyrase / genetics
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Drug Resistance, Multiple, Bacterial* / genetics
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Fluoroquinolones / pharmacology*
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Fluoroquinolones / therapeutic use
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Humans
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Microbial Sensitivity Tests
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Middle Aged
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Mutation
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Mycobacterium tuberculosis / drug effects*
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Mycobacterium tuberculosis / genetics
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Mycobacterium tuberculosis / isolation & purification
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Retrospective Studies
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Risk Factors
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Tuberculosis / drug therapy
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Tuberculosis / microbiology*
Substances
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Antitubercular Agents
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Fluoroquinolones
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DNA Gyrase