Abstract
The icsP promoter of Shigella spp. is repressed by H-NS and derepressed by VirB. Here, we show that an inverted repeat located between positions -1144 and -1130 relative to the icsP transcription start site is necessary for VirB-dependent derepression. The atypical location of this cis-acting site is discussed.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Bacterial Proteins / genetics*
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Bacterial Proteins / metabolism
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Base Sequence
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DNA-Binding Proteins / genetics*
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DNA-Binding Proteins / metabolism
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Down-Regulation*
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Gene Expression Regulation, Bacterial
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Molecular Sequence Data
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Promoter Regions, Genetic*
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Shigella flexneri / enzymology
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Shigella flexneri / genetics*
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Shigella flexneri / metabolism
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Transcription Initiation Site*
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Virulence Factors / genetics
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Virulence Factors / metabolism*
Substances
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Bacterial Proteins
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DNA-Binding Proteins
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H-NS protein, bacteria
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Virulence Factors
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SopA protein, Bacteria