Biomolecular assembly by iterative oxime ligations

Bioorg Med Chem Lett. 2009 Jul 15;19(14):3880-3. doi: 10.1016/j.bmcl.2009.03.119. Epub 2009 Mar 28.

Abstract

Herein we describe an iterative oxime-based procedure to prepare multivalent bioconjugates. Our approach is illustrated by the assembly of structurally diverse tetravalent and a new generation of hexadecavalent glycoclusters.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Chromatography, High Pressure Liquid
  • Glycoconjugates / chemical synthesis*
  • Glycoconjugates / chemistry
  • Oximes / chemical synthesis
  • Oximes / chemistry*
  • Peptides, Cyclic / chemistry
  • Spectrometry, Mass, Electrospray Ionization

Substances

  • Glycoconjugates
  • Oximes
  • Peptides, Cyclic