This paper outlines the life and career of Jessie Margaret Murray, the moving spirit behind the foundation of the Medico-Psychological Clinic, the first public clinic in Britain to offer psychoanalytic therapy and training in psychoanalysis. Biographical details of Murray and her close friend and collaborator, Julia Turner, are presented, and possible routes by which the two women may have met are explored. Murray's role in the suffragist movement is described, as well as other networks and professional societies in which she was involved, in particular the British Society for the Study of Sex Psychology, and her relationship with Marie Stopes. An account is given of events leading up to the founding of the Clinic, its activities, Murray's death, and other factors contributing to its demise. Finally, the Clinic's heritage and implications of the personalities of Murray and Turner for understanding the subsequent development of psycho-analysis in Britain are considered.