Abstract
Cells living in a complex environment must constantly detect, process and appropriately respond to changing signals. Therefore, all cellular information processing is dynamic in nature. As a consequence, understanding the process of signal transduction often requires detailed quantitative analysis of dynamic behaviours. Here, we focus on the oscillatory dynamics of the tumour suppressor protein p53 as a model for studying protein dynamics in single cells to better understand its regulation and function.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Ataxia Telangiectasia Mutated Proteins
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Calcium / metabolism
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Cell Cycle Proteins / physiology
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DNA Breaks, Double-Stranded
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DNA Repair
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DNA-Binding Proteins / physiology
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Humans
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Neoplasms / etiology
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Protein Processing, Post-Translational
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Protein Serine-Threonine Kinases / physiology
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Signal Transduction / physiology*
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Tumor Suppressor Protein p53 / physiology*
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Tumor Suppressor Proteins / physiology
Substances
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Cell Cycle Proteins
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DNA-Binding Proteins
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Tumor Suppressor Protein p53
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Tumor Suppressor Proteins
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ATM protein, human
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Ataxia Telangiectasia Mutated Proteins
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Protein Serine-Threonine Kinases
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Calcium