The ups and downs of p53: understanding protein dynamics in single cells

Nat Rev Cancer. 2009 May;9(5):371-7. doi: 10.1038/nrc2604. Epub 2009 Apr 9.

Abstract

Cells living in a complex environment must constantly detect, process and appropriately respond to changing signals. Therefore, all cellular information processing is dynamic in nature. As a consequence, understanding the process of signal transduction often requires detailed quantitative analysis of dynamic behaviours. Here, we focus on the oscillatory dynamics of the tumour suppressor protein p53 as a model for studying protein dynamics in single cells to better understand its regulation and function.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Ataxia Telangiectasia Mutated Proteins
  • Calcium / metabolism
  • Cell Cycle Proteins / physiology
  • DNA Breaks, Double-Stranded
  • DNA Repair
  • DNA-Binding Proteins / physiology
  • Humans
  • Neoplasms / etiology
  • Protein Processing, Post-Translational
  • Protein Serine-Threonine Kinases / physiology
  • Signal Transduction / physiology*
  • Tumor Suppressor Protein p53 / physiology*
  • Tumor Suppressor Proteins / physiology

Substances

  • Cell Cycle Proteins
  • DNA-Binding Proteins
  • Tumor Suppressor Protein p53
  • Tumor Suppressor Proteins
  • ATM protein, human
  • Ataxia Telangiectasia Mutated Proteins
  • Protein Serine-Threonine Kinases
  • Calcium