Advocacy for children is a fundamental pediatric concern and activity. Notwithstanding achievements for children to date, pediatrics can do more in the twenty-first century to advocate for children and promote research on ways in which advocacy for children can be improved. Evidence-based advocacy should take many directions including legislation, system change in local and state agencies such as social services and health departments, financial assistance including Medicaid, evidence provided to courts at trial and on appeal through "friend of the court" participation, family guidance, public education, and the promotion of pediatric law and bioethics.