Abstract
A chiral ligand- and lithium amide-assisted asymmetric conjugate addition of lithium enolate of propionate to cyclopentenecarboxylate gave the corresponding lithium enolate, whose allylation gave the key intermediate of the marine alkaloid halichlorine as a single diastereomer with moderate enantioselectivity.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkaloids / chemical synthesis*
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Alkaloids / chemistry
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Alkylation
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Catalysis
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Esters
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Lithium / chemistry*
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Molecular Structure
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Organometallic Compounds / chemistry*
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Spiro Compounds / chemical synthesis*
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Spiro Compounds / chemistry
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Stereoisomerism
Substances
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Alkaloids
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Esters
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Organometallic Compounds
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Spiro Compounds
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halichlorine
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Lithium