A retrospective study was carried out to evaluate which mesh (cadaveric fascia lata (Tutoplast or Prolene mesh) is associated with the best outcome of laparoscopic sacrocolpopexy for vaginal vault prolapse. Nineteen women who had surgery with Tutoplast and 20 who underwent surgery with Prolene were followed and asked to complete the Urogenital Distress Inventory and Defecation Distress Inventory to measure disease-specific quality of life. The women were invited for a follow-up visit for pelvic examination at a mean time of 45 months. There were no significant differences in operating time, blood loss or hospital stay between the groups. The risk of re-intervention because of recurrent prolapse was higher in the Tutoplast group than in the Prolene group (relative risk 2.9 (95% Confidence interval 0.9-9.5)). Women in the Prolene group were significantly more satisfied with the operative result.