Four-component reaction for the preparation of alpha-amino phosphonates from methyleneaziridines

Peter M Mumford; Gary J Tarver; Michael Shipman

doi:10.1021/jo9004958

Four-component reaction for the preparation of alpha-amino phosphonates from methyleneaziridines

J Org Chem. 2009 May 1;74(9):3573-5. doi: 10.1021/jo9004958.

Authors

Peter M Mumford¹, Gary J Tarver, Michael Shipman

Affiliation

¹ Department of Chemistry, University of Warwick, Gibbet Hill Road, Coventry, CV4 7AL, United Kingdom.

PMID: 19351179
DOI: 10.1021/jo9004958

Abstract

Alpha-amino phosphonates can be rapidly assembled in moderate to good yields (42-65%) via a "one-pot" process that brings together four components through the construction of three new intermolecular bonds.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aziridines / chemistry*
Organophosphonates / chemical synthesis
Organophosphonates / chemistry*

Substances

Aziridines
Organophosphonates

Grants and funding

Biotechnology and Biological Sciences Research Council/United Kingdom