Chemical weapons represent an ever-growing threat, not only for military forces but also for civilian populations. Nerve agents such as those used in terrorist attacks by the Aum sect in Tokyo are among the deadliest of those non conventional weapons. The French military health service has developed a new auto-injector presenting as a self-usable dual-chamber syringe and successfully obtained a new drug approval to provide this new emergency treatment for the military and civilians. After a short review of the pathophysiology and clinical presentation of acute nerve agent, the authors report the development and the process of new drug application. They finally suggest a clinical guideline for practical use in case of terrorist attack.