Fishing for a WNT-PGE2 link: beta-catenin is caught in the stem cell net-work

Todd Evans

doi:10.1016/j.stem.2009.03.006

Fishing for a WNT-PGE2 link: beta-catenin is caught in the stem cell net-work

Cell Stem Cell. 2009 Apr 3;4(4):280-2. doi: 10.1016/j.stem.2009.03.006.

Author

Todd Evans¹

Affiliation

¹ Department of Surgery, Weill Cornell Medical College, Cornell University, New York, NY 10021, USA. tre2003@med.cornell.edu

PMID: 19341616
DOI: 10.1016/j.stem.2009.03.006

Abstract

WNT and PGE2 signaling pathways are each associated with stem cell activity in the hematopoietic system. In a recent issue of Cell, Goessling et al. (2009) use the zebrafish model to reveal a conserved PKA-dependent mechanism that connects the two pathways via beta-catenin, enhancing stem cell proliferation and tissue regeneration.

MeSH terms

Animals
Cell Differentiation / physiology
Cell Line, Tumor
Cell Proliferation
Colonic Neoplasms / metabolism
Dinoprostone / metabolism*
Models, Animal
Signal Transduction / physiology
Stem Cells / metabolism*
Wnt Proteins / metabolism*
Zebrafish / metabolism*
Zebrafish Proteins / metabolism*
beta Catenin / metabolism*

Substances

Wnt Proteins
Zebrafish Proteins
beta Catenin
Dinoprostone