Abstract
The magnitude and character of adenovirus serotype 5 (Ad5)-specific T cells were determined in volunteers with and without preexisting neutralizing antibodies (NAs) to Ad5 who received replication-defective Ad5 (rAd5)-based human immunodeficiency virus vaccines. There was no correlation between T-cell responses and NAs to Ad5. There was no increase in magnitude or activation state of Ad5-specific CD4(+) T cells at time points where antibodies to Ad5 and T-cell responses to the recombinant gene products could be measured. These data indicate that rAd5-based vaccines containing deletions in the E1, E3, and E4 regions do not induce appreciable expansion of vector-specific CD4(+) T cells.
Publication types
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Research Support, N.I.H., Intramural
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Research Support, Non-U.S. Gov't
MeSH terms
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AIDS Vaccines / immunology
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Adenovirus Infections, Human / immunology*
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Adenovirus Infections, Human / virology
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Adenoviruses, Human / genetics*
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Adenoviruses, Human / immunology
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Antibodies, Viral / blood
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Antibodies, Viral / immunology
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CD4-Positive T-Lymphocytes / immunology*
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CD8-Positive T-Lymphocytes / immunology
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Defective Viruses / genetics
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Gene Deletion*
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Genes, Viral
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Genetic Vectors*
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HIV Infections / immunology
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HIV Infections / prevention & control
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HIV-1 / immunology
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Humans
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Lymphocyte Activation / immunology
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Neutralization Tests
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env Gene Products, Human Immunodeficiency Virus / immunology
Substances
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AIDS Vaccines
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Antibodies, Viral
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env Gene Products, Human Immunodeficiency Virus