Abstract
A series of tricyclic analogues of acyclovir and 9-{[cis-1',2'-bis(hydroxymethyl)cycloprop-1'-yl]methyl}guanine substituted in the 6 position with thien-2-yl, 5-bromothien-2-yl or furan-2-yl group were synthesized. The new compounds 5a-f were evaluated for their activity in vitro against varicella-zoster virus (VZV) and cytomegalovirus (CMV). The marked anti-VZV activities of 5a-f remained comparable to those of their previously described 6-phenyl-substituted counterparts.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acyclovir / analogs & derivatives
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Acyclovir / chemical synthesis*
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Acyclovir / pharmacology*
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Antiviral Agents / chemical synthesis*
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Antiviral Agents / chemistry
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Antiviral Agents / pharmacology*
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Cell Line
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Guanine / analogs & derivatives*
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Guanine / chemical synthesis
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Guanine / chemistry
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Guanine / pharmacology
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Herpesvirus 3, Human / drug effects*
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Humans
Substances
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9-((cis-1,2-bis(hydroxymethyl)cycloprop-1-yl)methyl)guanine
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Antiviral Agents
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Guanine
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Acyclovir