Abstract
Cathepsin K is a member of the papain family of cysteine proteases and is highly expressed in osteoclasts that mediate bone resorption. In this review, some of the known features of cathepsin K such as structure, function in bone resorption, gene regulation and its roles in physiological or pathophysiological processes are highlighted.
MeSH terms
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Bone Resorption / drug therapy*
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Bone Resorption / enzymology*
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Bone Resorption / genetics
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Cathepsin K
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Cathepsins / antagonists & inhibitors*
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Cathepsins / genetics
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Cathepsins / metabolism*
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Dysostoses / genetics
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Gene Expression Regulation
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Humans
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Osteoclasts / enzymology*
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Protein Conformation
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Tissue Distribution
Substances
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Cathepsins
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CTSK protein, human
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Cathepsin K