Regulation of LMO2 mRNA and protein expression in erythroid differentiation

Haematologica. 2009 Apr;94(4):447-8. doi: 10.3324/haematol.2008.005140.

Abstract

Proliferation, differentiation, and survival of erythroid progenitors are ultimately controlled through activation and repression of specific genetic programs. In this perspective article, Drs. Brandt and Koury examine the role of LIM domain-only protein 2 (LMO2) as an important transcriptional regulator in erythropoiesis. See related article on page 479.

Publication types

  • Comment
  • Editorial
  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Adaptor Proteins, Signal Transducing
  • Cell Differentiation / genetics*
  • DNA-Binding Proteins / analysis
  • DNA-Binding Proteins / genetics*
  • Erythrocytes / cytology*
  • Erythropoiesis / genetics
  • Gene Expression Regulation / physiology*
  • Humans
  • LIM Domain Proteins
  • Metalloproteins / analysis
  • Metalloproteins / genetics*
  • Proto-Oncogene Proteins
  • RNA, Messenger / analysis

Substances

  • Adaptor Proteins, Signal Transducing
  • DNA-Binding Proteins
  • LIM Domain Proteins
  • LMO2 protein, human
  • Metalloproteins
  • Proto-Oncogene Proteins
  • RNA, Messenger