Opisthorchiasis mimicking primary biliary cirrhosis as an indication for liver transplantation

J Hepatol. 2009 May;50(5):1057-9. doi: 10.1016/j.jhep.2008.11.029. Epub 2009 Mar 14.

Abstract

Background/aims: Opisthorchiasis, a helminthic infection occurring endemically in certain areas of Europe and Asia is caused by parasites of the class trematoda. Failure to treat or a significant delay in the institution of an adequate therapy can lead to considerable complications in the further course of the disease.

Case: A 56-year-old patient diagnosed with primary biliary cirrhosis (PBC) with Child-Pugh stage B was referred to our surgical department from a peripheral hospital for liver transplantation. She had spent 50 years of her life in Kazakhstan.

Results: As the treatment of choice, orthotopic liver transplantation was carried out. The routine postoperative pathological analysis of the explanted liver showed the histological picture of opisthorchiasis. Further work-up in an effort to confirm the histological diagnosis was repeatedly negative.

Conclusions: Opisthorchiasis should always be a diagnostic consideration in an unclear case of chronic liver disease especially in patients living in endemic areas.

Publication types

  • Case Reports
  • Research Support, N.I.H., Extramural

MeSH terms

  • Diagnosis, Differential
  • Endemic Diseases
  • Female
  • Humans
  • Kazakhstan
  • Liver Cirrhosis, Biliary / diagnosis*
  • Liver Transplantation*
  • Middle Aged
  • Opisthorchiasis / diagnosis*
  • Opisthorchiasis / epidemiology
  • Opisthorchiasis / surgery*