Background and objective: To compare macular thicknesses in healthy subjects measured with spectral domain optical coherence tomography (SD-OCT) (Cirrus; Carl Zeiss Meditec, Inc., Dublin, CA) with measurements using time domain (TD-OCT) (Stratus; Carl Zeiss Meditec, Inc.).
Patients and methods: Macular thickness was measured five times in the same eye of 10 healthy subjects with both Cirrus and Stratus to assess reliability and then once in the same eye of 50 healthy subjects with both Cirrus and Stratus to compare the average obtained by each device.
Results: Using TD-OCT, the coefficient of variations (CV) of the macular thicknesses within a 1-mm central area ranged from 0.7% to 3.3% (mean, 1.33%); with SD-OCT, the range was 0.2% to 1.3% (mean, 0.66%). The mean CV with SD-OCT was significantly smaller than with TD-OCT (P < .05). The average macular thicknesses with TD-OCT and SD-OCT were 197.2 +/- 17.8 microm and 257.6 +/- 19.6 microm, respectively. However, the correlation was significant (correlation coefficient, 0.916, P<.001).
Conclusion: Cirrus showed better reliability than Stratus. Using SD-OCT, the macula was 60-microm thicker than when measured with TD-OCT. Attention should be given to comparing data obtained using different OCT machines.