Relationships between the structures of flavanone derivatives and their effects in enhancing early growth response-1 gene expression

Sunhee Lee; Yoonkyung Woo; Soon Young Shin; Young Han Lee; Yoongho Lim

doi:10.1016/j.bmcl.2009.03.017

Relationships between the structures of flavanone derivatives and their effects in enhancing early growth response-1 gene expression

Bioorg Med Chem Lett. 2009 Apr 15;19(8):2116-20. doi: 10.1016/j.bmcl.2009.03.017. Epub 2009 Mar 10.

Authors

Sunhee Lee¹, Yoonkyung Woo, Soon Young Shin, Young Han Lee, Yoongho Lim

Affiliation

¹ Division of Bioscience and Biotechnology, BMIC, RCD, Konkuk University, Seoul, Republic of Korea.

PMID: 19307119
DOI: 10.1016/j.bmcl.2009.03.017

Abstract

To identify the structural requirements that are pivotal in enhancing Early growth response-1 (Egr-1) expression, the quantitative relationships between the structural properties of flavanone derivatives and their increments of Egr-1 expression were elucidated using comparative molecular field analysis and comparative molecular similarity indices analysis.

Publication types

Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

Early Growth Response Protein 1 / biosynthesis*
Early Growth Response Protein 1 / genetics*
Flavanones / chemistry*
Flavanones / pharmacology
Gene Expression Regulation / drug effects
Gene Expression Regulation / physiology*
HeLa Cells
Humans
Quantitative Structure-Activity Relationship

Substances

Early Growth Response Protein 1
Flavanones